AKT/GSK3β/NFATc1 and ROS signal axes are involved in AZD1390-mediated inhibitory effects on osteoclast and OVX-induced osteoporosis
Shuyue Yang, Dezhi Song, Ziyi Wang, Yuangang Su, Junchun Chen, Yansi Xian, Jian Huang, Jing Li, Jiake Xu, Jinmin Zhao, Qian Liu
Topics & Concepts
OsteoclastRANKLOxidative stressBone resorptionReactive oxygen speciesProtein kinase BOsteoporosisSignal transductionCell biologyChemistryCancer researchPI3K/AKT/mTOR pathwayMedicineInternal medicineActivator (genetics)BiologyBiochemistryIn vitroGeneBone Metabolism and DiseasesNF-κB Signaling PathwaysBone health and treatments