c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation
Ya-Chu Tang, Jenn-Ren Hsiao, Shih-Sheng Jiang, Jang‐Yang Chang, Pei‐Yi Chu, Ko‐Jiunn Liu, Hsun-Lang Fang, Li-Mei Lin, Huang-Hui Chen, Yen‐Wen Huang, Yu-Tsen Chen, Fang-Yu Tsai, Su‐Fang Lin, Yung‐Jen Chuang, Ching‐Chuan Kuo
Abstract
Carcinogens trigger c-MYC-directed NRF2 activation. Over-activation of NRF2 promotes malignant progression of HNSCC through reprogramming G6PD- and TKT-mediated nucleotide biosynthesis. Targeting NRF2-directed cellular metabolism is an effective strategy for development of novel treatments for head and neck cancer.
Topics & Concepts
Cancer researchHead and neck squamous-cell carcinomaBiologyCancerCarcinogenesisTumor progressionTransketolaseLactate dehydrogenase AChemistryLactate dehydrogenaseHead and neck cancerBiochemistryEnzymeGeneticsGenomics, phytochemicals, and oxidative stressMicroRNA in disease regulationCircular RNAs in diseases