Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure
Mark E. Pepin, Chae‐Myeong Ha, Luke Potter, Sayan Bakshi, Joseph P. Barchue, Ayman Asaad, Steven M. Pogwizd, Salpy V. Pamboukian, Bertha Hidalgo, Selwyn M. Vickers, Adam R. Wende
Abstract
A bimodal signature of cardiac DNA methylation in heart failure corresponds with racial differences in all-cause mortality following mechanical circulatory support. Racial differences in promoter methylation disproportionately affect metabolic signaling pathways. Socioeconomic factors are associated with racial differences in the cardiac methylome among men with end-stage heart failure.
Topics & Concepts
Heart failureSocioeconomic statusDNA methylationMethylationRacial differencesInternal medicineMedicineCardiologyBiologyGeneticsGeneEthnic groupGene expressionEnvironmental healthPopulationAnthropologySociologyHeart Failure Treatment and ManagementCardiac Structural Anomalies and RepairMechanical Circulatory Support Devices