Preparation and biological properties of silk fibroin/nano-hydroxyapatite/graphene oxide scaffolds with an oriented channel-like structure
Qian Zhang, Min Fang, Yijing Xia, Jiaxin Hou, Xiaoru Nan, Bin Zhao, Xiangyu Wang
Abstract
, osteogenic induction was carried out on BMSCs inoculated on the above scaffolds, and then alkaline phosphatase (ALP) activity was tested and cell mineralization was observed. The results indicated that the oriented channel-like SF/nHAp/GO porous scaffold was more conducive to osteogenic differentiation of BMSCs. Hence, the material may prove to be a promising scaffold for bone tissue engineering.
Topics & Concepts
FibroinGrapheneNano-Materials scienceSILKNanotechnologyOxideChemical engineeringComposite materialMetallurgyEngineeringSilk-based biomaterials and applicationsBone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applications