Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models
Samantha Sheller‐Miller, Enkhtuya Radnaa, Jae‐Kwang Yoo, Kyungsun Choi, Youngeun Kim, Yu Na Kim, Eunsoo Kim, Lauren Richardson, Chulhee Choi, Ramkumar Menon
Abstract
≥ 4). Furthermore, using a transgenic model in which fetal tissues express the red fluorescent protein tdTomato while maternal tissues do not, we report that LPS-induced PTB in mice is associated with influx of fetal innate immune cells, not maternal, into feto-maternal uterine tissues. SR packaged in exosomes provides a stable and specific intervention for reducing the inflammatory response associated with PTB.
Topics & Concepts
MicrovesiclesFetusImmune systemInflammationImmunologyMedicineNF-κBDrug deliveryDrugPharmacologyBiologyChemistryPregnancymicroRNAGeneticsGeneOrganic chemistryPreterm Birth and ChorioamnionitisReproductive System and PregnancyPregnancy and preeclampsia studies