Research priorities for measuring biologic age: summary and future directions from the Research Centers Collaborative Network Workshop
Tina E. Brinkley, Jamie N. Justice, Shubhashrita Basu, Scott R. Bauer, Kah Poh Loh, Péter Mukli, Ted Kheng Siang Ng, Indira C. Turney, Luigi Ferrucci, Steven R. Cummings, Stephen B. Kritchevsky
Abstract
Biologic aging reflects the genetic, molecular, and cellular changes underlying the development of morbidity and mortality with advancing chronological age. As several potential mechanisms have been identified, there is a growing interest in developing robust measures of biologic age that can better reflect the underlying biology of aging and predict age-related outcomes. To support this endeavor, the Research Centers Collaborative Network (RCCN) conducted a workshop in January 2022 to discuss emerging concepts in the field and identify opportunities to move the science forward. This paper presents workshop proceedings and summarizes the identified research needs, priorities, and recommendations for measuring biologic age. The highest priorities identified were the need for more robust measures, longitudinal studies, multidisciplinary collaborations, and translational approaches.