Targeting complement C3 with Tanshinone I decreases microglia-mediated synaptic engulfment to exert antidepressant effects
Huaqing Lai, Pinglong Fan, Pengxiang Zhang, Meng Zhang, Xinmu Li, Boyu Kuang, Run Zhou, Wenfei Wang, Hongchi Jiang, Zhen‐Zhen Wang, Nai‐Hong Chen
Abstract
Collectively, the study demonstrated that Tan I acts as a potent natural C3 modulator that binds directly to C3, blocks the C3-CR3 axis and downstream signal transducer and activator of transcription 3 (STAT3) signaling pathway, inhibits microglia-mediated synaptic engulfment, and improves fMRI-based network changes, which in turn exert antidepressant effects.
Topics & Concepts
MicrogliaAntidepressantNeuroscienceChemistryComplement (music)Complement systemPharmacologyMedicineInflammationBiologyImmune systemImmunologyHippocampusBiochemistryPhenotypeGeneComplementationNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersStress Responses and Cortisol