High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRAS<sup>G12C</sup> by Intact Protein MS and Targeted MRM
Ke Sherry Li, John G. Quinn, Matthew J. Saabye, Jesus F. Salcido Guerrero, Jim Nonomiya, Qihui Lian, Wilson Phung, Yevgeniy Izrayelit, Benjamin T. Walters, Amy Gustafson, Nicholas Endres, Maureen H. Beresini, Melinda M. Mulvihill
Abstract
.
Topics & Concepts
ChemistryCovalent bondMass spectrometryCombinatorial chemistryChromatographyOrganic chemistryClick Chemistry and ApplicationsComputational Drug Discovery MethodsChemical Synthesis and Analysis