Identifying drug targets in tissues and whole blood with thermal-shift profiling
Jessica Perrin, Thilo Werner, Nils Kurzawa, Anna Rutkowska, Dorothee Childs, Mathias Kalxdorf, Daniel Poeckel, Eugenia Stonehouse, Katrin Strohmer, Bianca Heller, Douglas W. Thomson, Jana Krause, Isabelle Becher, H. Christian Eberl, Johanna Vappiani, Daniel C. Sévin, Christina Rau, Holger Franken, Wolfgang Huber, Maria Faelth-Savitski, Mikhail M. Savitski, Marcus Bantscheff, Giovanna Bergamini
Topics & Concepts
PanobinostatProteomeIn vivoVemurafenibChemistryWhole bloodHistone deacetylase inhibitorBiologyCancer researchHistone deacetylaseHistoneBiochemistryDNAMelanomaImmunologyMetastatic melanomaBiotechnologyHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsUbiquitin and proteasome pathways