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Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site

Xiangyu Yan, Jiafu Leng, Tingting Chen, Yongjun Zhao, Ling‐Yi Kong, Yong Yin

2022European Journal of Medicinal Chemistry17 citationsDOI

Topics & Concepts

ChemistryHeLaCell cycleTubulinApoptosisDocking (animal)Cell cycle checkpointCyclin-dependent kinase 1AngiogenesisCell growthBiochemistryCellMolecular biologyMicrotubuleCancer researchCell biologyBiologyNursingMedicineSynthesis and biological activityCancer Mechanisms and TherapyCancer therapeutics and mechanisms
Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site | Litcius