Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity
Chi Zhang, Weiyun Li, Xiaobo Lei, Zhenfei Xie, Linlin Qi, Hui Wang, Hui Wang, Xia Xiao, Jun Xiao, Yuxiao Zheng, Dong Chen, Xin Zheng, Shiyang Chen, Jianfeng Chen, Bing Sun, Jun Qin, Qiwei Zhai, Jinsong Li, Bin Wei, Jianwei Wang, Hongyan Wang, Hongyan Wang
Abstract
to suppress IRF3 activation. Targeting LPA1 or ROCK in macrophages, fibroblasts, epithelial cells, and LPA1 conditional KO mice promoted interferon-induced clearance of multiple viruses. LPA1 was colocalized with the receptor ACE2 in lung and intestine. Together with previous findings that LPA1 and ROCK1/2 promoted vascular leaking or lung fibrosis, we propose that the current available preclinical drugs targeting the LPA1-ROCK module might protect from SARS-CoV-2 or various virus infections in the intestine or lung.