<i>In Silico</i> Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis
Kirsten E. Knoll, Mietha M. Van der Walt, Du Toit Loots
Abstract
This article elaborates on the mechanism of action of a novel antibiotic compound against both, active and dormant Mycobacterium tuberculosis and describes its pharmacokinetics (including oral bioavailability and toxicity). Information provided in this article serves useful during the search for drugs that shorten the treatment regimen for Tuberculosis and cause minimal adverse effects.
Topics & Concepts
In silicoDrugMycobacterium tuberculosisTuberculosisDrug discoveryComputational biologyBiologyPharmacologyMedicineBioinformaticsGeneticsGenePathologyTuberculosis Research and EpidemiologyComputational Drug Discovery MethodsCancer therapeutics and mechanisms