Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
Hyuk‐Kwon Kwon, Inkyu Lee, Kristin E. Yu, Sean V. Cahill, Kareme D. Alder, Saelim Lee, Christopher M. Dussik, Jungho Back, Jeongjoon Choi, Lee Song, Themis R. Kyriakides, Francis Y. Lee
Abstract
within joint cells. Furthermore, mitigation of intra-articular inflammation by targeting the NLRP3 (nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3) inflammasome protects articular cartilage from damage in a murine model of knee septic arthritis. Together, concurrent mitigation of intra-articular inflammation and local adjuvant targeting of intracellular bacteria represents a promising new therapeutic strategy for septic arthritis.
Topics & Concepts
Septic arthritisInflammationMedicinePyrin domainArthritisInflammasomeCartilageImmunologyAntibioticsMicrobiologyBiologyAnatomyOrthopedic Infections and TreatmentsAntimicrobial Peptides and ActivitiesStreptococcal Infections and Treatments