The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells
Malka Cohen‐Armon
Abstract
This overview summarizes recent data disclosing the efficacy of the PARP inhibitor PJ34 in exclusive eradication of a variety of human cancer cells without impairing healthy proliferating cells. Its cytotoxic activity in cancer cells is attributed to the insertion of specific un-repairable anomalies in the structure of their mitotic spindle, leading to mitotic catastrophe cell death. This mechanism paves the way to a new concept of cancer therapy.
Topics & Concepts
MitosisCancer cellMechanism (biology)PhenanthridineCancerCancer researchMitotic catastropheCell biologyCytotoxic T cellProgrammed cell deathBiologyChemistryApoptosisGeneticsIn vitroPhysicsQuantum mechanicsPARP inhibition in cancer therapyDNA Repair MechanismsCancer therapeutics and mechanisms