Targeting Prolyl 4-Hydroxylase Subunit Beta (P4HB) in Cancer: New Roads to Travel
Dechao Feng, Jie Wang, Dengxiong Li, Ruicheng Wu, Zhouting Tuo, Qingxin Yu, Luxia Ye, Akira Miyamoto, Koo Han Yoo, Cheng Wang, Yuanzhi Cheng, Xing Ye, Chi Zhang, Wuran Wei
Abstract
Prolyl 4-hydroxylase subunit beta (P4HB) can catalyze the formation, breakage and rearrangement of disulfide bonds through two thioredoxin domains, which is important for the maintenance of oxidizing environment in endoplasmic reticulum. Recently, P4HB has been demonstrated its oncogenic role of tumorigenesis and development in cancers. Therefore, we comprehensively deciphered P4HB in human cancer from various aspects, including pan-cancer analysis and narrative summary. We also provided some possible interacted molecules and the top 10 predicted drugs targeting P4HB to contribute to future research. We proposed that P4HB was a potential target and brought new therapeutic opportunities for cancer patients.