IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr <sup>1250</sup> and Tyr <sup>1251</sup>
Leonie Rieger, Sandra O’Shea, Grant Godsmark, Joanna Stanicka, Geraldine Kelly, Rosemary O’Connor
Abstract
promoted IGF-1R translocation to and signaling from the Golgi to support an aggressive cancer phenotype. This process distinguishes IGF-1R from IR signaling and could contribute to the poor clinical efficacy of antibodies that target IGF-1R on the cell surface.
Topics & Concepts
Golgi apparatusChromosomal translocationPhosphorylationReceptorCancer cellCell biologyAdhesionCell adhesionChemistryCancerCellBiologyBiochemistryGeneGeneticsOrganic chemistryGrowth Hormone and Insulin-like Growth FactorsMetabolism, Diabetes, and CancerGlycosylation and Glycoproteins Research