Microneedle-mediated delivery of MIL-100(Fe) as a tumor microenvironment-responsive biodegradable nanoplatform for O<sub>2</sub>-evolving chemophototherapy
Sulan Luo, Yiting Zhao, Kewei Pan, Yixian Zhou, Guilan Quan, Xinguo Wen, Xin Pan, Chuanbin Wu
Abstract
MIL-100(Fe) nanoparticles integrated microneedles were employed to codeliver the hydrophobic photosensitizer zinc phthalocyanine (ZnPc) and the chemotherapeutical drug doxorubicin hydrochlorate (Dox) (Z/D@MOF) for O 2 -evolving chemophototherapy.
Topics & Concepts
DoxorubicinChemistryBiocompatibilityHydrogen peroxideIn vivoReactive oxygen speciesPhotodynamic therapyTumor microenvironmentDoxorubicin HydrochlorideDrug deliveryPhthalocyanineTumor hypoxiaSinglet oxygenNanotechnologyBiophysicsCancer researchOxygenMaterials scienceBiochemistryTumor cellsOrganic chemistryRadiation therapyChemotherapySurgeryBiologyMedicineBiotechnologyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesNanoparticle-Based Drug Delivery