Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020
Katrin Kremer, Rolf Kramer, Bernd Neumann, Sebastian Haller, Niels Pfennigwerth, Guido Werner, Sören Gatermann, Horst Schroten, Tim Eckmanns, Jörg B. Hans
Abstract
in 13 German federal states prompted us to initiate an outbreak investigation. Whole genome sequencing revealed that among 148 isolates analysed, most belonged to sequence type 38 with 62 isolates forming a genetically distinct cluster. Although no epidemiological link could be identified between cases, ongoing investigations suggest non-healthcare associated transmission. A screening-PCR was developed facilitating early detection of ST38 cluster isolates to identify the source and transmission route.
Topics & Concepts
OutbreakEscherichia coliTransmission (telecommunications)Cluster (spacecraft)Molecular epidemiologyWhole genome sequencingBiologyGenomeGermanGeneticsVirologyGeographyGeneGenotypeComputer scienceTelecommunicationsProgramming languageArchaeologyAntibiotic Resistance in BacteriaEscherichia coli research studiesBacteriophages and microbial interactions