Concise Total Synthesis of Peyssonnoside A
Gleb A. Chesnokov, Karl Gademann
Abstract
Peyssonnoside A is a marine-derived sulfated diterpenoid glucoside with a unique 5/6/3/6 tetracyclic skeleton with a highly substituted cyclopropane ring deeply embedded into the structure. Herein, we report the first total synthesis of this natural product in a concise, efficient, scalable, and highly diastereoselective fashion. The aglucone peyssonnosol was synthesized in 21% overall yield after 15 steps, featuring a Simmons-Smith cyclopropanation and Mukaiyama hydration, fully controlled by the spatial structure of the substrates.
Topics & Concepts
ChemistryTotal synthesisCyclopropanationCyclopropaneNatural productYield (engineering)StereochemistryRing (chemistry)Organic chemistryCatalysisMaterials scienceMetallurgySynthetic Organic Chemistry MethodsMarine Sponges and Natural ProductsCarbohydrate Chemistry and Synthesis