Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway
Dejiang Pang, Chengcheng Yang, Qihui Luo, Chao Li, Wentao Liu, Lixia Li, Yuanfeng Zou, Bin Feng, Zhengli Chen, Chao Huang
Abstract
, suggesting an improved effect of soy isoflavones on hypothalamic antioxidant defense is mediated by PGC-1α. Our study reveals a potential mechanism of soy isoflavones regulating oxidative stress induced hypothalamic inflammation and cellular apoptosis, which will be important for obesity treatment.
Topics & Concepts
GenisteinIsoflavonesOxidative stressEndocrinologyInternal medicineDaidzeinInflammationCoactivatorMedicineBiologyBiochemistryTranscription factorGeneAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityDiet, Metabolism, and Disease