Microbiota of the Pregnant Mouse: Characterization of the Bacterial Communities in the Oral Cavity, Lung, Intestine, and Vagina through Culture and DNA Sequencing
Jonathan M. Greenberg, Roberto Romero, Andrew D. Winters, José Galaz, Valeria Garcia‐Flores, Marcia Arenas‐Hernandez, Jonathan Panzer, Zachary Shaffer, David J. Kracht, Nardhy Gomez‐Lopez, Kevin R. Theis
Abstract
in humans, suggesting potential ecological parallels. Importantly, we report that the vaginal microbiota of the pregnant mouse can be readily cultured under hypoxic conditions, demonstrating that mock microbial communities can be utilized to test the potential ecological parallels between microbiotas in human and murine pregnancy and to evaluate the relevance of the structure of these microbiotas for adverse pregnancy outcomes, especially intra-amniotic infection and preterm birth.
Topics & Concepts
VaginaLungBiologyPregnancyGestationAmniotic fluidOral cavityFetusMedicineAnatomyInternal medicineGeneticsOrthodonticsGut microbiota and healthReproductive System and PregnancyInfant Nutrition and Health