Oxalate Metabolism: From Kidney Stones to Cardiovascular Disease
Gerlineke Hawkins-van der Cingel, Stephen B. Walsh, Kai‐Uwe Eckardt, Felix Knauf
Abstract
Oxalate kidney stones are common and exert a huge burden of morbidity worldwide. However, circulating or excreted concentrations of oxalate are rarely measured. We argue that oxalate and its metabolism are important above and beyond kidney stone formation. There is emerging evidence that increased concentrations of oxalate could be a driver of chronic kidney disease progression. Furthermore, oxalate has been implicated in cardiovascular disease. Thus, the reduction of elevated plasma oxalate concentrations may represent a novel cardioprotective and nephroprotective strategy.
Topics & Concepts
OxalateMedicineKidney stonesKidneyKidney diseaseMetabolismDiseaseCalcium oxalateInternal medicineEndocrinologyUrinary systemChemistryOrganic chemistryKidney Stones and Urolithiasis TreatmentsPorphyrin Metabolism and DisordersCassava research and cyanide