Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway
Anrong Wang, Lian-fang Mi, Zhi-lei Zhang, Mingzhe Hu, Zeyu Zhao, Bin Liu, Yanbin Li, Shu Zheng
Topics & Concepts
CREBDentate gyrusHippocampusBehavioural despair testNeurotrophic factorsHippocampal formationEndocrinologyInternal medicineBrain-derived neurotrophic factorTUNEL assayMedicineIschemiaPharmacologyNeurosciencePsychologyChemistryImmunohistochemistryAntidepressantBiochemistryTranscription factorReceptorGeneNeuroinflammation and Neurodegeneration MechanismsNatural product bioactivities and synthesisPharmacological Effects of Natural Compounds