Prevention and Treatment of Radiation-Induced Lung Injury
Chengcheng Xia, Weiyan Shi, Yuyu Zhang, Lijuan Ding, Ling Gao, Qiang Wang, Lihong Shao, Lihua Dong, Yan Gao
Abstract
Radiation-induced lung injury (RILI) is a common complication in cancer patients receiving local thoracic radiation and bone marrow transplantation conditioning. It is divided into early-stage radiation pneumonitis and advanced radiation fibrosis of the lung. This severely hampers the quality of life and survival of cancer patients. Meanwhile, RILI is a major factor limiting radiation doses in clinical practice, which affects the local control of cancer. Unfortunately, the mechanism of RILI is still not well defined, and there are no treatment options available for these patients. In this review we summarize the methods and agents used for the treatment and prevention of RILI, with the aim of increasing understanding of RILI.