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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

Siddhant U. Jain, Andrew Q. Rashoff, Samuel D. Krabbenhoft, Dominik Hoelper, J. Truman, Tyler J. Gibson, Stefan Lundgren, Eliana R. Bondra, Shriya Deshmukh, Ashot S. Harutyunyan, Nikoleta Juretic, Nada Jabado, Melissa M. Harrison, Peter W. Lewis

2020Molecular Cell146 citationsDOIOpen Access PDF

Topics & Concepts

Histone H3BiologyPRC2ChromatinLysineCell biologyHistoneMethylationCpG siteMethyltransferaseDrosophila melanogasterBiochemistryDNA methylationAmino acidDNAGene expressionGeneEpigenetics and DNA MethylationGenomics and Chromatin DynamicsRNA modifications and cancer
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2 | Litcius