A scalable and green one-minute synthesis of substituted phenols
Vijayaragavan Elumalai, Jørn H. Hansen
Abstract
/HBr as the reagent under unprecedentedly simple and convenient conditions. A wide range of arylboronic acids were smoothly transformed into substituted phenols in very good to excellent yields without chromatographic purification. The reaction is scalable up to at least 5 grams at room temperature with one-minute reaction time and can be combined in a one-pot sequence with bromination and Pd-catalyzed cross-coupling to generate more diverse, highly substituted phenols.
Topics & Concepts
PhenolsScalabilityChemistryCombinatorial chemistryComputer sciencePulp and paper industryOrganic chemistryEngineeringOperating systemSynthesis of Indole DerivativesChemical Synthesis and ReactionsRadical Photochemical Reactions