Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure
Stephen T. Decker, Oh‐Sung Kwon, Jia Zhao, John R. Hoidal, Thomas Heuckstadt, Russell S. Richardson, Karl Sanders, Gwenaël Layec
Abstract
It is unclear whether the exercise intolerance and skeletal muscle mitochondrial dysfunction observed in patients with COPD is due to cigarette smoke exposure, per se, or if they are secondary consequences to inactivity. Herein, while long-term exposure to cigarette smoke induces oxidative stress and an altered skeletal muscle phenotype, cigarette smoke does not directly contribute to mitochondrial dysfunction. With this evidence, we demonstrate the critical role of physical inactivity in cigarette smoke-related skeletal muscle dysfunction.
Topics & Concepts
Oxidative stressSkeletal muscleCOPDInternal medicineEndocrinologyUCP3Respiratory systemCitrate synthaseChemistryMitochondrionInflammationOxidative phosphorylationBiologyMedicineBiochemistryUncoupling proteinEnzymeObesityBrown adipose tissueChronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyAdipose Tissue and Metabolism