Synthesis and degradation mechanism of renally excretable gold core–shell nanoparticles for combined photothermal and photodynamic therapy
Barkha Singh, Chetna Patnaik, Rohan Bahadur, Mayuri Gandhi, Abhijit De, Rohit Srivastava
Abstract
toxicity research. The mechanism of cell death is studied using ROS and cell cycle analysis. The material exhibited good efficacy as a PTT agent in mice and showed non-toxicity up to 14 days. The renal clearance study of the material in mice shows its disintegration into renal clearable minute gold seeds. All the findings suggest biodegradable glutathione-functionalized gold core-shell nanoparticles as potential photothermal cancer treatment agents.
Topics & Concepts
Photothermal therapyPhotodynamic therapyNanoparticleNanotechnologyMechanism (biology)Materials scienceColloidal goldChemistryOrganic chemistryEpistemologyPhilosophyNanoplatforms for cancer theranosticsGold and Silver Nanoparticles Synthesis and ApplicationsPhotoacoustic and Ultrasonic Imaging