Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan
Tsutomu Yoshida, Go Ogura, Mikiko Tanabe, Takuo Hayashi, Chiho Ohbayashi, Mizutomo Azuma, Chikara Kunisaki, Yoichi Akazawa, Soji Ozawa, Sohei Matsumoto, Takayoshi Suzuki, Akira Mitoro, Tetsu Fukunaga, Akiko Shimizu, Go Fujimoto, Takashi Yao
Abstract
< .0001). The prevalence of PD-L1 positivity among Japanese patients was comparable to that in previous pembrolizumab clinical trials and studies in gastric cancer. Particularly, higher PD-L1 expression was observed in MSI-H tumors.
Topics & Concepts
Microsatellite instabilityMedicineAdenocarcinomaInternal medicinePD-L1GastroenterologyStage (stratigraphy)CancerEsophagogastric junctionImmunohistochemistryOncologyImmunotherapyBiologyGeneBiochemistryPaleontologyMicrosatelliteAlleleGastric Cancer Management and OutcomesGastrointestinal Tumor Research and TreatmentCancer Immunotherapy and Biomarkers