Characterizing block-copolymer micelles used in nanomedicines via solution static scattering techniques
Isamu Akiba, Kazuo Sakurai
Abstract
Abstract Block copolymers are well recognized as excellent nanotools for delivering hydrophobic drugs. The formulation of such delivery nanoparticles requires robust characterization and clarification of the critical quality attributes correlating with the safety and efficacy of the drug before applying to regulatory authorities for approval. Static solution scattering from block copolymers is one such technique. This paper first outlines the theoretical background and current models for analyzing this scattering and then presents an overview of our recent studies on block copolymers.
Topics & Concepts
CopolymerMicelleScatteringDynamic light scatteringMaterials scienceCharacterization (materials science)Block (permutation group theory)NanotechnologyNanoparticleComputer scienceChemistryPolymerPhysicsOrganic chemistryMathematicsOpticsAqueous solutionComposite materialGeometryAdvanced Polymer Synthesis and CharacterizationNanoparticle-Based Drug DeliveryBlock Copolymer Self-Assembly