Hawthorn fruit extract ameliorates H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in neuronal PC12 cells and prolongs the lifespan of <i>Caenorhabditis elegans via</i> the IIS signaling pathway
Xinxin Wang, Xin Li, Luyi Li, Yang Xu, Jilite Wang, Xiaozhi Liu, Jingnan Chen, Suwen Liu, Nan Zhang, Jing Li, Hao Wang
Abstract
, paraquat, juglone, ultraviolet radiation, and heat shock. HFE also suppressed the accumulation of aging pigments, improved the body bending ability, increased antioxidant enzyme activities, and reduced the contents of ROS and malondialdehyde. In addition, relevant gene expression, lifespan experiments with mutant strains, and molecular docking studies supported the results that HFE might extend lifespan through the IIS signal pathway.
Topics & Concepts
Superoxide dismutaseReactive oxygen speciesOxidative stressMalondialdehydeCatalaseAntioxidantSignal transductionGlutathione peroxidaseCaenorhabditis elegansPharmacologyBiochemistryChemistrySOD2BiologyGeneBotanical Studies and ApplicationsFungal Biology and ApplicationsMicrobial Metabolism and Applications