Combined photothermal-immunotherapy <i>via</i> poly-tannic acid coated PLGA nanoparticles for cancer treatment
Xingyue Huang, Xuehao Tian, Qing Zhang, Haiyan Hu, Jiahui Gao, Baonan Ma, Kai Wu, Jie Bai, Shouying Du, Yang Lu, Ning Han
Abstract
60 °C and effectively suppressed the growth of primary tumors. What's more, the progression of distant tumors as well as lung metastasis was also significantly inhibited due to the activation of anti-tumor responses by PLGA-pTA mediated PTT. When further combined with anti-PD-L1 antibody (a-PD-L1), the tumor growth and metastasis were almost completely inhibited. Our study provided a versatile platform to achieve combined photothermal-immunotherapy with enhanced therapeutic efficacy.
Topics & Concepts
Tannic acidPhotothermal therapyPLGANanoparticleChemistryImmunotherapyCancer immunotherapyCancerNanotechnologyBiophysicsMaterials scienceMedicineBiologyOrganic chemistryInternal medicineNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseImmunotherapy and Immune Responses