Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition
Pranav Gupta, Hongling Zhao, Bang H. Hoang, Edward L. Schwartz
Topics & Concepts
Ubiquitin ligaseCell cycleSKP2BiologyUbiquitinCancer researchCell biologyOncogeneF-box proteinRetinoblastoma proteinProtein degradationCell growthCellBiochemistryGeneCancer-related Molecular PathwaysUbiquitin and proteasome pathwaysMicrotubule and mitosis dynamics