IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards
David M. DeMarini, William M. Gwinn, Emily Watkins, Brad Reisfeld, Weihsueh A. Chiu, Lauren Zeise, Dinesh Kumar Barupal, Parveen Bhatti, Kevin P. Cross, Eugenia Dogliotti, Jason M. Fritz, Dori R. Germolec, Maria Helena Guerra Andersen, Kathryn Z. Guyton, Jennifer Jinot, David H. Phillips, Roger R. Reddel, N. Rothman, Martin van den Berg, Roel Vermeulen, Paolo Vineis, Amy Wang, Maurice Whelan, Akram Ghantous, Michael Korenjak, Jiří Zavadil, Zdenko Herceg, Sandra Pérdomo, Laure Dossus, Shirisha Chittiboyina, Danila Cuomo, John Kaldor, Elisa Pasqual, Gabrielle Rigutto, Roland Wedekind, Caterina Facchin, Fatiha El Ghissassi, Aline de Conti, Mary K. Schubauer‐Berigan, Federica Madia
Abstract
BACKGROUND: programme has successfully applied the KCs framework for the mechanistic evaluation of different types of exposures, including chemicals, metals, and complex exposures, such as environmental, occupational, or dietary exposures. The use of this framework has significantly enhanced the identification and organization of relevant mechanistic data, minimized bias in evaluations, and enriched the knowledge base regarding the mechanisms of known and suspected carcinogens. OBJECTIVES: evaluations. METHODS: ) the integration of the mechanistic evidence as part of cancer hazard identification. The workshop participants assessed the relevance and the informativeness of multiple KCs-associated end points for the evaluation of mechanistic evidence in studies of exposed humans and experimental systems. DISCUSSION: or in other contexts. https://doi.org/10.1289/EHP15389.