The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model
Yue Zhu, Zhiyu Li, Yujia Zhang, Fang Lan, Jing He, Yao Wu
Abstract
Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.
Topics & Concepts
OsteoblastOsteoclastMicrovesiclesScaffoldCell biologyExosomeCell growthOsteoporosisChemistryMaterials scienceInternal medicineBiomedical engineeringMedicineIn vitroBiologyBiochemistrymicroRNAGeneExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery