Efficacy, Biocompatibility and Degradability of Carbon Nanoparticles for Photothermal Therapy of Lung Cancer
Ida Kokalari, Sandeep Keshavan, Mizanur Rahman, Elena Gazzano, Giulia Barzan, Luisa Mandrile, Andrea Mario Giovannozzi, Jessica Ponti, Giulia Antonello, Marco P. Monopoli, Guido Perrone, Enrico Bergamaschi, Chiara Riganti, Bengt Fadeel, Ivana Fenoglio
Abstract
Aim: To investigate near infrared-induced phototoxicity toward lung cancer cells, and the biodegradability and effect on immune cells of glucose-derived carbon nanoparticles (CNPs). Methods: The human A549 lung adenocarcinoma cell line was used as a model to study the phototoxicity of CNPs. The biodegradability and the effect on immune cells was demonstrated in primary human neutrophils and macrophages. Results: Near infrared-activated CNPs elicited rapid cell death, characterized by the elevation of heat shock proteins and the induction of DNA damage. CNPs were found to be noncytotoxic toward primary human macrophages and were susceptible to biodegradation when cocultured with human neutrophils. Conclusions: Our results identify CNPs as promising platforms for photothermal therapy of lung cancer.