Aortic stiffness is lower when PVAT is included: a novel ex vivo mechanics study
Tyler Tuttle, Emma S. Darios, Stephanie W. Watts, Sara Roccabianca
Abstract
We introduce a novel and physiologically relevant way of measuring perivascular adipose tissue (PVAT) mechanical stiffness which shows that PVAT's low, yet measurable, stiffness is linearly correlated with the amount of collagen fibers present within the tissue. Including PVAT in the measurement of the aortic wall's mechanical behavior is important, and it significantly affects the resulting metrics by decreasing aortic stiffness.
Topics & Concepts
StiffnessAortaEx vivoThoracic aortaBiomedical engineeringMaterials scienceMechanicsInternal medicineIn vivoMedicineComposite materialPhysicsBiotechnologyBiologyCardiovascular Disease and AdiposityCardiovascular Health and Disease PreventionAortic aneurysm repair treatments