Perspectives on parity violation in chiral molecules: theory, spectroscopic experiment and biomolecular homochirality
Martin Qüack, Georg Seyfang, Gunther Wichmann
Abstract
), depending on the molecule, but which has not yet been detected experimentally. Its detection remains one of the great challenges of current physical-chemical stereochemistry, with implications also for fundamental problems in physics. In biochemistry and molecular biology one finds a related fundamental question unanswered for more than 100 years: the evolution of 'homochirality', which is the practically exclusive preference of one chiral, enantiomeric form as building blocks in the biopolymers of all known forms of life (the l-amino acids in proteins and d-sugars in DNA, not the reverse d-amino acids or l-sugars). In astrobiology the spectroscopic detection of homochirality could be used as strong evidence for the existence of extraterrestrial life, if any. After a brief conceptual and historical introduction we review the development, current status, and progress along these three lines of research: theory, spectroscopic experiment and the outlook towards an understanding of the evolution of biomolecular homochirality.