Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras
Tapé Kouamé, Okpekon Aboua Timothée, Nicaise F. Bony, Amon Diane Marina N’Tamon, Jean‐François Gallard, Somia Rharrabti, Karine Leblanc, Elisabeth Mouray, Philippe Grellier, Pierre Champy, Mehdi A. Beniddir, Pierre Le Pogam
Abstract
Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.