Microemulgel: a novel approach for topical drug delivery
Priya Kushwah, Pravin Kumar Sharma, Sweta S Koka, Ashish Gupta, Ravi Kumar Sharma, G. N. Darwhekar
Abstract
Topical drug delivery is mostly preferred for dermatological action. Topical dosage form such as cream, ointments, gels etc. has certain drawbacks like stability problems, stickiness, poor absorption as well as permeability. It has limitations in terms of drug solubility, residence time, lipophilicity and permeability. To overcome this, a novel approach microemulsion based gel is formulated. Microemulgel is topical drug delivery system that incorporates the properties of both gel and microemulsion and shows dual release control system. The microemulgel is prepared by reducing the globule size of the emulsion (less than 200nm) so that the drug particles can easily penetrate through stratum corneum. In spite of penetration, microemulgel has several advantages like easily spreadable, non-grease, thixotropic, transparent, and bio-friendly. Currently many drugs of antimicrobial, antifungal and non-steroidal anti-inflammatory class are studied for topical delivery through microemulgel formulation. After the brief study, it can be concluded that the microemulgel appear better and effective delivery system as compared to other topical drug delivery system