The Synthesis of α-Keto Acetals from Terminal Alkynes and Alcohols via Synergistic Interaction of Organoselenium Catalysis and Electrochemical Oxidation
Ding Ding, Liang Xu, Yu Wei
Abstract
Herein, an unprecedented electrochemical approach for the synthesis of α-keto acetals has been established from readily available terminal alkynes and alcohols. By merging the electrochemical and organoselenium-catalyzed processes, the desired products are obtained at room temperature in the absence of basic or metallic additives, with carbonyl and acetal motifs incorporated simultaneously across the triple bonds in a single operation.
Topics & Concepts
AcetalElectrochemistryCatalysisChemistryCombinatorial chemistryMetalTriple bondTerminal (telecommunication)Organic chemistryDouble bondComputer scienceElectrodePhysical chemistryTelecommunicationsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsOrganoselenium and organotellurium chemistry