Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy
Haowei Wu, Peipei Zhang, Jiedong Zhou, Songqing Hu, Jinjin Hao, Zuoquan Zhong, Haijun Yu, Juntao Yang, Jufang Chi, Hangyuan Guo
Abstract
This study demonstrated for the first time that paeoniflorin (PA) exerts protective effects in diabetic cardiomyopathy mice by alleviating myocardial damage, resisting ferroptosis, and changing the community composition and structure of the intestinal microbiota, and 11,12-epoxyeicosatrienoic acid (11,12-EET) may serve as a key contributor in its therapeutic efficacy.
Topics & Concepts
PaeoniflorinGut floraDiabetic cardiomyopathyTransplantationCardiomyopathyMetabolomicsOxidative stressPharmacologyIn vivoLipid peroxidationMedicineBiologyChemistryHeart failureBiochemistryInternal medicineBioinformaticsBiotechnologyHigh-performance liquid chromatographyChromatographyFerroptosis and cancer prognosisCancer-related molecular mechanisms researchImmune cells in cancer