A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
Jing Han, Shuhao Zhang, Yanfei Hou, Yi Wang, Zhengyin Zhang, Jiaming Yang, Yifang Xu, Zexu Peng, Hang Yin, Kehong Chen, Xiangyu Liu, Conggang Zhang
Topics & Concepts
StingStimulator of interferon genesBiologyTransmembrane proteinHelix (gastropod)Cell biologyGolgi apparatusInnate immune systemSignal transductionInterferonTransmembrane domainBiochemistryAgonistReceptorVenominterferon and immune responsesVirology and Viral DiseasesMosquito-borne diseases and control