Enantiospecificity in Organic Photoelectrochemical Transistors Enabled by Chirality-Induced Spin Selectivity Effects
Jian‐Hong Zhu, Xinzhe Yang, Yulin Zheng, Shujia Wang, Zhen-Kun He, Zhida Gao, Yan‐Yan Song
Abstract
Chirality, as an intrinsic feature of the living world, is associated with many significant biological processes. Although the chiral-induced spin selectivity (CISS) effects have been recognized and applied to provide spin control over chemical reactions, their implementation in the organic electrochemical transistor (OECT) remains a largely unexplored area. Herein, the OECT technology is combined with a photovoltaic gate electrode and the CISS effect, establishing a chiral organic photoelectrochemical transistor (OPECT) for enantiomer identification. The chiral Sn(II)-based metal–organic framework (SnMOF)/SnO 2 hybrid, serving as a spin filter to induce CISS properties, is coated on a TiO 2 nanotube array-based photosensitive gate. Using cystine enantiomers as proof-of-principle, a target recognition-induced electron donor ( l -/ d -cysteine) generation was further proposed. The CISS effect enables a more efficient transfer of spin-polarized electrons between the L-target and L-gate (or between the D-target and D-gate), inducing a greater channel current ( I D ) variation. The comprehensive analysis of the I D responses in the two chiral OPECT sensors further enables accurate and reliable determination of the concentration and composition of enantiomers in unknown mixtures. This study provides a straightforward methodology to apply the CISS effect for determining chiral targets in complex samples.