Intraspecies Signaling between Common Variants of Pseudomonas aeruginosa Increases Production of Quorum-Sensing-Controlled Virulence Factors
Dallas L. Mould, Nico J. Botelho, Deborah A. Hogan
Abstract
Coculture interactions between lasR loss-of-function and LasR+ Pseudomonas aeruginosa strains may explain the worse outcomes associated with the presence of LasR− strains. More broadly, this report illustrates how interactions within a genotypically diverse population, similar to those that frequently develop in natural settings, can promote unpredictably high virulence factor production.
Topics & Concepts
Quorum sensingPseudomonas aeruginosaVirulenceMicrobiologyBiologyVirulence factorBacteriaGeneticsGeneBacterial biofilms and quorum sensingVibrio bacteria research studiesBiosensors and Analytical Detection