Palladium Catalyzed Selective B(3)–H Activation/Oxidative Dehydrogenative Coupling for the Synthesis of Bis(<i>o</i>-carborane)s
Ji Wu, Ke Cao, Caiyan Zhang, Tao‐Tao Xu, Xin‐Yu Wen, Bo Li, Junxiao Yang
Abstract
A palladium catalyzed selective B(3)–H activation/oxidative dehydrogenative coupling for the synthesis of bis( o -carborane)s connected with B(3)–B(3′) and B(3)–B(6′) bonds has been developed for the first time. A plausible mechanism involving stepwise activation of B(3)–H and B(3′/6′)–H bonds by Pd II and Pd IV was proposed. This work is the first example and the most efficient protocol for synthesis of bis( o -carborane)s connected with B(3)–B(3′) and B(3)–B(6′) bonds, which has important reference for design, synthesis, and application of bis( o -carborane)s in related fields.
Topics & Concepts
ChemistryCarboranePalladiumCatalysisOxidative phosphorylationOxidative additionCoupling (piping)StereochemistryMedicinal chemistryOrganic chemistryBiochemistryMechanical engineeringEngineeringBoron Compounds in ChemistryMedical Imaging Techniques and ApplicationsOrthopedic Infections and Treatments