Biogeography of microbial bile acid transformations along the murine gut
Solenne Marion, Lyne Desharnais, Nicolas Studer, Yuan Dong, Matheus D. Notter, Suresh Poudel, Laure Menin, Andrew Janowczyk, Robert L. Hettich, Siegfried Hapfelmeier, Rizlan Bernier‐Latmani
Abstract
). Furthermore, the bile acid profile in mice with a more complex microbiota, a dysbiosed microbiota, or no microbiota was considered. For instance, conventional mice harbor a large diversity of bile acids, but treatment with an antibiotic such as clindamycin results in the complete inhibition of 7α-dehydroxylation, underscoring the strong inhibition of organisms that are capable of carrying out this process by this compound. Finally, a comparison of the hepatic bile acid pool size as a function of microbiota revealed that a reduced microbiota affects host signaling but not necessarily bile acid synthesis. In this study, bile acid transformations were mapped to the associated active microorganisms, offering a systematic characterization of the relationship between microbiota and bile acid composition.