Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis
Wenbiao Chen, Donge Tang, Junqi Lin, Xiaoming Huang, Shaoming Lin, Guanle Shen, Yong Dai
Abstract
. Thus, exosomal circSHKBP1 participated in the progression of NSCLC via the miR-1294/PKM2 axis. circSHKBP1 may be potential biomarker for the diagnosis and treatment of NSCLC.
Topics & Concepts
MicrovesiclesCancer researchDownregulation and upregulationLung cancerPKM2microRNAExosomeCell growthMetastasisTumor progressionMedicineGlycolysisOncologyBiologyCancerInternal medicinePyruvate kinaseGeneGeneticsBiochemistryMetabolismCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research