Drug Transport System Based on Phospholipid Nanoparticles: Production Technology and Characteristics
E.G. Tikhonova, Maxim A. Sanzhakov, Yulia A. Tereshkina, L.V. Kostryukova, Yulia Yu. Khudoklinova, Nadezhda A. Orlova, Daria V. Bobrova, O. M. Ipatova
Abstract
One of the current trends in modern pharmaceuticals is the supply of drugs by transport systems. The use of delivery systems allows to increase the therapeutic efficacy, tolerability, and safety of drug therapy. Liposomes, polymer nanoparticles, carbon nanoparticles, blood cells, metal nanoparticles, oxides, etc., are used as transport systems. This work is aimed at obtaining a finished technological product based on soy phospholipids with particle size in the nanometer range and reproducible characteristics (size, charge). For this purpose, we carried out investigations to select the optimal conditions of technological process. The developed technology makes it possible to obtain phospholipid nanoparticles without the use of any solubilizers and/or surfactants, which increases its practical relevance for further work. The versatility of the technology is demonstrated by the example of incorporation of drugs of various chemical nature and pharmacotherapeutic groups.