Cannabidiol protects C2C12 myotubes against cisplatin-induced atrophy by regulating oxidative stress
Olivier Le Bacquer, Phelipe Sanchez, Véronique Patrac, César Rivoirard, N. Saroul, Christophe Giraudet, Ayhan Kocer, Stéphane Walrand
Abstract
In an in vitro model, cisplatin treatment led to myotube atrophy associated with dysregulation of protein homeostasis and increased oxidative stress, resulting in increased apoptosis. Cotreatment with cannabidiol was able to prevent this phenotype by promoting protein homeostasis and reducing oxidative stress.
Topics & Concepts
Oxidative stressCannabidiolMyogenesisC2C12AtrophyCisplatinHomeostasisApoptosisMuscle atrophyCell biologyChemistryPharmacologyBiologyEndocrinologyInternal medicineMyocyteMedicineBiochemistryChemotherapyPsychiatryCannabisParkinson's Disease Mechanisms and TreatmentsChemotherapy-induced organ toxicity mitigationCoenzyme Q10 studies and effects